玻璃体腔内注射贝伐单抗（阿瓦斯汀）治疗视网膜下液和黄斑水肿的直肠癌转移患者的疗效：短期随访
Effect of treatment of rectal cancer metastasis with intravitreal bevacizumab (Avastin) in patient with subretinal fluid and macular oedema: short-term follow-up.
作者信息
Boss Joseph Daniel, Lieu Philip, Tewari Asheesh
机构信息
Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, USA Department of Ophthalmology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Kresge Eye Institute, Detroit, Michigan, USA.
出版信息
BMJ Case Rep. 2016 Sep 2;2016:bcr2016216273. doi: 10.1136/bcr-2016-216273.
Abstract
We describe the management of subretinal fluid and macular oedema due to colorectal cancer metastasis to the choroid using intravitreal bevacizumab. A patient with grade VI KRAS mutation rectal cancer with metastasis to the lung and cerebellum presented with left eye choroidal metastasis 1 week after being started on the experimental medication KTN3379. After intravitreal bevacizumab administration, the patient had improvement in macular subretinal fluid, but eventually progressed to severe cystoid macular oedema despite monthly intravitreal bevacizumab treatment.
摘要
我们描述了使用玻璃体内注射贝伐单抗治疗因结直肠癌转移至脉络膜所致的视网膜下液和黄斑水肿的情况。一名患有VI级KRAS突变直肠癌且已转移至肺和小脑的患者，在开始使用实验性药物KTN3379 1周后出现左眼脉络膜转移。玻璃体内注射贝伐单抗后，患者黄斑下视网膜下液有所改善，但尽管每月进行玻璃体内贝伐单抗治疗，最终仍进展为严重的黄斑囊样水肿。
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