Cosenzi A, Franca G, Piemontesi A, Bellini G
G Clin Med. 1989 Jan;70(1):19-25.
Many experimental evidences suggest an important role of calcium in the pathophysiology of essential hypertension; an increased calciuria could be a feature of these patients. Provocative tests, such as cold pressor test or aerobic exercise, have been proposed to be predictive for the occurrence of essential hypertension. Aim of this study has been to show a relation between sodium, calcium and potassium urinary excretion and blood pressure response to provocative tests in young normotensives with a positive parental history for essential hypertension. The subjects of the study were 59 young normotensive volunteers, 30 with a positive and 29 with a negative parental history for essential hypertension. All subjects underwent a cold pressor test and a maximal aerobic exercise on a bicycle ergometer; blood pressure and heart rate were recorded before, during and after the tests by means of an automatic device. An overnight urine collection allowed the evaluation of sodium, potassium and calcium excretion. There was no difference between the two groups as to blood pressure response to provocative tests or to urinary electrolyte excretion. Only in subjects with a positive parental history for essential hypertension there was linear correlation between calcium urinary excretion and systolic blood pressure, both baseline and exercise-induced.
许多实验证据表明钙在原发性高血压的病理生理学中起重要作用；尿钙增加可能是这些患者的一个特征。已提出诸如冷加压试验或有氧运动等激发试验可预测原发性高血压的发生。本研究的目的是在有原发性高血压阳性家族史的年轻血压正常者中，显示尿钠、钙和钾排泄与激发试验的血压反应之间的关系。该研究的受试者为59名年轻血压正常的志愿者，其中30名有原发性高血压阳性家族史，29名有阴性家族史。所有受试者均接受冷加压试验和在自行车测力计上进行最大有氧运动；通过自动装置在试验前、试验期间和试验后记录血压和心率。收集过夜尿液以评估钠、钾和钙的排泄。两组在激发试验的血压反应或尿电解质排泄方面没有差异。仅在有原发性高血压阳性家族史的受试者中，尿钙排泄与收缩压之间存在线性相关性，包括基线收缩压和运动诱发的收缩压。
