Czarkowski M, Chojnowski K, Osikowska-Loksztejn M, Chodakowska J
Kliniki Nadciśnienia Tetniczego i Chorób Naczyń AM, Warszawie.
Pol Tyg Lek. 1994;49(10-11):225-7.
An exaggerated pressor reaction to the isometric exercise and cold pressor test (CPT) is found to be a predictor or future hypertension. In the two groups of young males: 51 men with positive family history of essential hypertension (EH) (mean age: 24.3 +/- 3.3 years, group S) and 11 men with negative history of EH (mean age: 23.5 +/- 3.7 years, group K) the blood pressure responsiveness to the handgrip test (HG) and CPT were evaluated. Ambulatory systolic (SBP) and diastolic (DBP) blood pressure were higher in S then K (respectively: 136 +/- 11/81 +/- 10 mm Hg vs 126 +/- 4/76 +/- 6 mm Hg, p < 0.05). The elevation of blood pressure after HG (30% of maximal voluntary contraction for 3 min.) was higher in K than S (respectively: delta SBP = 37 +/- 20 vs 21 +/- 17 mm Hg i delta DBP = 27 +/- 20 vs 7 +/- 12 mm Hg, p < 0.05). Similarly, after CPT (by immersing the left hand and forearm in ice-cold water for 2 min.) the elevation of blood pressure was higher in K than S (respectively: delta SBP = 22 +/- 11 vs 12 +/- 12 mm Hg i delta DBP = 17 +/- 12 vs 9 +/- 9 mm Hg, p < 0.05). These results do not confirm an exaggerated blood pressure responsiveness to the HG test or CPT in young males with positive family history of EH, irrespectively to the diagnosis of normotension or borderline hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
研究发现，对等长运动和冷加压试验（CPT）的升压反应过度是未来患高血压的一个预测指标。在两组年轻男性中：51名有原发性高血压（EH）家族史阳性的男性（平均年龄：24.3±3.3岁，S组）和11名无EH家族史的男性（平均年龄：23.5±3.7岁，K组），评估了他们对手握力试验（HG）和CPT的血压反应性。S组的动态收缩压（SBP）和舒张压（DBP）高于K组（分别为：136±11/81±10 mmHg对126±4/76±6 mmHg，p<0.05）。K组在HG（最大自主收缩的30%，持续3分钟）后血压升高幅度高于S组（分别为：ΔSBP = 37±20对21±17 mmHg，ΔDBP = 27±20对7±12 mmHg，p<0.05）。同样，在CPT后（将左手和前臂浸入冰水中2分钟），K组的血压升高幅度高于S组（分别为：ΔSBP = 22±11对12±12 mmHg，ΔDBP = 17±12对9±9 mmHg，p<0.05）。这些结果并未证实有EH家族史阳性的年轻男性对HG试验或CPT的血压反应过度，无论其诊断为正常血压还是临界高血压。（摘要截断于250字）
