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III级和IV级钝性胰腺创伤非手术治疗成功的预测因素。

Predictors of successful non-operative management of grade III & IV blunt pancreatic trauma.

作者信息

Koganti Suman B, Kongara Ravikanth, Boddepalli Sateesh, Mohammad Naushad Shaik, Thumma Venumadhav, Nagari Bheerappa, Sastry R A

机构信息

Department of Gastrointestinal Surgery, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana (Andhra Pradesh), 500082, India.

Department of Bio-statistics & Pharmacogenomics, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana (Andhra Pradesh), 500082, India.

出版信息

Ann Med Surg (Lond). 2016 Aug 9;10:103-9. doi: 10.1016/j.amsu.2016.08.003. eCollection 2016 Sep.

Abstract

INTRODUCTION

Although surgery is the preferred treatment for grade III&IV pancreatic trauma, there is a growing movement for non-operative management. in blunt pancreatic trauma. Very few studies compare operative versus non-operative management in adult patients.

METHODS

Retrospective analysis of a prospectively maintained database was performed from 2004 to 2013 in the department of gastrointestinal surgery, NIMS, Hyderabad. Comparative analysis was performed between patients who failed versus those who were successfully managed with non-operative management.

RESULTS

34 patients had grade III/IV trauma out of which 8 were operated early with the remaining 26 initially under a NOM strategy, 10 of them could be successfully managed without any operation. Post-traumatic pancreatitis, Necrotizing pancreatitis, Ileus, contusion on CT, surrounding organ injuries are independently associated with failure of NOM on a univariate analysis. On multivariate logistic regression presence of necrosis& associated organ injury are factors that predict failure of NOM independently. Development of a pseudocyst is the only significant factor that is associated with a success of NOM.

CONCLUSIONS

Non-operative measures should be attempted in a select group of grade III&IV blunt pancreatic trauma. In hemodynamically stable patients with a controlled leak walled off as a pseudocyst without associated organ injuries and pancreatic necrosis, NOM has a higher success rate.

摘要

引言

尽管手术是Ⅲ级和Ⅳ级胰腺创伤的首选治疗方法,但对于钝性胰腺创伤,非手术治疗的趋势正在增加。很少有研究比较成年患者手术与非手术治疗的效果。

方法

对2004年至2013年在海得拉巴NIMS胃肠外科前瞻性维护的数据库进行回顾性分析。对非手术治疗失败的患者与成功接受非手术治疗的患者进行比较分析。

结果

34例患者为Ⅲ/Ⅳ级创伤,其中8例早期接受手术治疗,其余26例最初采用非手术治疗策略,其中10例无需任何手术即可成功治疗。单因素分析显示,创伤后胰腺炎、坏死性胰腺炎、肠梗阻、CT上的挫伤、周围器官损伤与非手术治疗失败独立相关。多因素逻辑回归分析显示,坏死和相关器官损伤是独立预测非手术治疗失败的因素。假性囊肿的形成是与非手术治疗成功相关的唯一重要因素。

结论

对于部分Ⅲ级和Ⅳ级钝性胰腺创伤患者,应尝试采取非手术措施。对于血流动力学稳定、渗漏得到控制且形成假性囊肿、无相关器官损伤和胰腺坏死的患者,非手术治疗成功率较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c91/4995476/9478d77efddd/gr1.jpg

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