Auriault F, Thollon L, Pérès J, Behr M
Aix-Marseille Univ, IFSTTAR, LBA UMR_T24, F-13016, France.
Aix-Marseille Univ, IFSTTAR, LBA UMR_T24, F-13016, France.
Accid Anal Prev. 2016 Dec;97:96-102. doi: 10.1016/j.aap.2016.08.026. Epub 2016 Sep 2.
This study documents the development of adverse fetal outcome predictors dedicated to the analysis of road accidents involving pregnant women. To do so, a pre-existing whole body finite element model representative of a 50th percentile 26 weeks pregnant woman was used. A total of 8 accident scenarios were simulated with the model positioned on a sled. Each of these scenarios was associated to a risk of adverse fetal outcome based on results from real car crash investigations involving pregnant women from the literature. The use of airbags and accidents involving unbelted occupants were not considered in this study. Several adverse fetal outcome potential predictors were then evaluated with regard to their correlation to this risk of fetal injuries. Three predictors appeared strongly correlated to the risk of adverse fetal outcome: (1) the intra uterine pressure at the placenta fetal side area (r=0.92), (2) the fetal head acceleration (HIC) (r=0.99) and (3) area of utero-placental interface over a strain threshold (r=0.90). Finally, sensitivity analysis against slight variations of the simulation parameters was performed and assess robustness of these criteria.
本研究记录了用于分析涉及孕妇交通事故的不良胎儿结局预测指标的开发过程。为此,使用了一个现有的全身有限元模型,该模型代表第50百分位的26周孕妇。在一个雪橇上放置该模型,总共模拟了8种事故场景。根据文献中涉及孕妇的真实车祸调查结果,这些场景中的每一个都与不良胎儿结局风险相关。本研究未考虑安全气囊的使用以及涉及未系安全带乘客的事故。然后评估了几个潜在的不良胎儿结局预测指标与胎儿损伤风险的相关性。三个预测指标与不良胎儿结局风险高度相关:(1)胎盘胎儿侧区域的宫内压力(r = 0.92),(2)胎儿头部加速度(头部损伤标准值,HIC)(r = 0.99),以及(3)超过应变阈值的子宫 - 胎盘界面面积(r = 0.90)。最后,针对模拟参数的微小变化进行了敏感性分析,并评估了这些标准的稳健性。