School of Pharmaceutical Science and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, Jinan, Shandong Province 250012, PR China.
Int J Pharm. 2011 Oct 31;419(1-2):240-6. doi: 10.1016/j.ijpharm.2011.07.008. Epub 2011 Jul 18.
This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger-Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.
本工作介绍了一种将亲水性抗癌药物 5-氟尿嘧啶（5-Fu）负载到羧甲基纤维素钠亚微米纤维中的新途径。结果表明，5-Fu 成功地掺入到具有良好稳定性、所需药物负载量和 100%包封效率的生物相容性聚合物羧甲基纤维素钠（NaCMC）纤维中。此外，所制备的载药纤维的药物释放速率可以得到很好的控制。负载 5-Fu 的 NaCMC 纤维的药物释放行为呈现扩散机制，符合 Ritger-Peppas 动力学模型。所制备产物的药物释放行为表明它们在药物传递系统中有很好的应用前景。
