Morovati Atefeh, Ahmad Panahi Homayon, Yazdani Farzaneh
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Int J Pharm. 2016 Nov 20;513(1-2):62-67. doi: 10.1016/j.ijpharm.2016.09.006. Epub 2016 Sep 3.
In this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and allylimidazole with affinity toward celecoxib onto magnetic nano-particles. The grafted nano-particles were characterized by Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The surface morphology was studied using Scanning Electron Microscopy. The resulting grafted nano-particles were used for the determination of trace celecoxib in biological human fluids and pharmaceutical samples. The profile of celecoxib uptake by the modified magnetic nano-particles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. Solid phase extraction for biological fluids such as urine and serum were investigated. In this study, urine extraction recovery of more than 95% was obtained.
在本研究中，报道了一种将作为热敏剂的N-乙烯基己内酰胺和对塞来昔布具有亲和力的烯丙基咪唑表面接枝到磁性纳米颗粒上的新方法。通过傅里叶变换红外光谱、元素分析和热重分析对接枝的纳米颗粒进行了表征。使用扫描电子显微镜研究了表面形态。所得接枝纳米颗粒用于测定生物人体体液和药物样品中的痕量塞来昔布。改性磁性纳米颗粒对塞来昔布的摄取情况表明接枝共聚物中活性位点具有良好的可及性。发现吸附行为可以用朗缪尔吸附等温线模型拟合。研究了尿液和血清等生物流体的固相萃取。在本研究中，尿液萃取回收率超过95%。
