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接枝到改性磁性纳米颗粒上的聚[ - 异丙基丙烯酰胺 - - 3 - 烯丙氧基 - 1,2 - 丙二醇]的合成、表征及应用

The synthesis, characterization and applications of poly[-isopropylacrylamide--3-allyloxy-1,2-propanediol] grafted onto modified magnetic nanoparticles.

作者信息

Alipour Arash, Shekardasht Mehrnaz Babaei, Gharbani Parvin

机构信息

Department of Chemistry, Science and Research Branch, Islamic Azad University Tehran Iran.

Department of Chemistry, Ahar Branch, Islamic Azad University Ahar Iran

出版信息

RSC Adv. 2020 Jan 22;10(6):3511-3519. doi: 10.1039/c9ra09105j. eCollection 2020 Jan 16.

DOI:10.1039/c9ra09105j
PMID:35497763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9048845/
Abstract

In this paper, a novel method is investigated for the extraction, determination, and delivery of ceftazidime in simulated gastric and real biological fluids such as serum plasma and urine in drug delivery systems. A new polymer as a nano-sorbent was synthesized by the surface grafting of [-isopropylacrylamide--3-allyloxy-1,2-propanediol] onto modified magnetic nano-particles by 3-mercaptopropyltrimethoxysilane and it was characterized by FT-IR, CHN, SEM, TEM, VSM, TGA, and zeta potential analyses. The effects of main parameters such as pH, reaction time, temperature, and solvents were evaluated for ceftazidime removal. The results indicate that the newly synthesized polymer can be successfully applied for biomedical applications and drug delivery.

摘要

本文研究了一种在药物递送系统中，用于在模拟胃液以及血清血浆和尿液等真实生物流体中提取、测定和递送头孢他啶的新方法。通过3-巯丙基三甲氧基硅烷将[-异丙基丙烯酰胺- -3-烯丙氧基-1,2-丙二醇]接枝到改性磁性纳米颗粒表面，合成了一种新型聚合物作为纳米吸附剂，并通过傅里叶变换红外光谱（FT-IR）、元素分析（CHN）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）、振动样品磁强计（VSM）、热重分析（TGA）和zeta电位分析对其进行了表征。评估了pH值、反应时间、温度和溶剂等主要参数对头孢他啶去除率的影响。结果表明，新合成的聚合物可成功应用于生物医学应用和药物递送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/3e2beaad63cb/c9ra09105j-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/f84999c37902/c9ra09105j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/226910acc4ad/c9ra09105j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/62533978dd3f/c9ra09105j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/ba81cd238da2/c9ra09105j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/71632ddc22cc/c9ra09105j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/b29812003812/c9ra09105j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/3e2beaad63cb/c9ra09105j-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/f84999c37902/c9ra09105j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/226910acc4ad/c9ra09105j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/62533978dd3f/c9ra09105j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/ba81cd238da2/c9ra09105j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/71632ddc22cc/c9ra09105j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/b29812003812/c9ra09105j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c93c/9048845/3e2beaad63cb/c9ra09105j-f7.jpg

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