孟加拉异距蝎抗蛇毒血清的免疫交叉反应性和副特异性
Immunological cross reactivity & paraspecificity of the scorpion Heterometrus bengalensis antivenom.
作者信息
Das Gupta S C, Gomes A, Gomes A, Basu A, Lahiri S C
出版信息
Indian J Med Res. 1989 Apr;90:140-6.
Immunological cross-reactivity and paraspecificity of scorpion H. bengalensis antivenom were studied to find out the intergeneric therapeutic relationship between the venom of other scorpions in West Bengal Buthus tamulus, Lychas laevifrons and Heterometrus swammerdami. Of these scorpions, Buthus tamulus and Lychas laevifrons failed to show any cross reactivity. However, H. swammerdami venom showed cross-reactivity with H. bengalensis antiserum as revealed from immunogeldiffusion and immunoelectrophoresis. This antiserum protected H. swammerdami venom-induced lethality in mice, blocked the contractile response in smooth muscles and antagonised the venom-induced neuromuscular blockade in rat phrenic nerve diaphragm and chick biventer cervicis.
研究了孟加拉金蝎抗蛇毒血清的免疫交叉反应性和副特异性，以找出西孟加拉邦其他蝎子（如印度杀人蝎、细纹狼蝎和帝王蝎）毒液之间的属间治疗关系。在这些蝎子中，印度杀人蝎和细纹狼蝎未表现出任何交叉反应。然而，免疫凝胶扩散和免疫电泳显示，帝王蝎毒液与孟加拉金蝎抗血清表现出交叉反应。这种抗血清可保护小鼠免受帝王蝎毒液诱导的致死作用，阻断平滑肌的收缩反应，并拮抗毒液诱导的大鼠膈神经膈肌和鸡双腹肌神经肌肉阻滞。
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