Gwadz R W, Kaslow D, Lee J Y, Maloy W L, Zasloff M, Miller L H
Malaria Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Infect Immun. 1989 Sep;57(9):2628-33. doi: 10.1128/iai.57.9.2628-2633.1989.
Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from giant silk moths. In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes previously infected with a variety of Plasmodium species, both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocysts; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes coding for magainins, cecropins, or similarly acting parasiticidal peptides into the mosquito genome.
蛙皮素和杀菌肽是分别源自青蛙皮肤或巨型蚕蛾的具有广泛抗菌和抗寄生虫活性的肽家族。在昆虫中，杀菌肽作为诱导免疫系统对抗多种细菌感染的一部分发挥作用。当将蛙皮素和杀菌肽注射到先前感染了多种疟原虫物种的按蚊中时，它们会通过使卵囊的正常发育中止来破坏孢子生殖发育；不会形成子孢子，并且载体无法将寄生虫传播给另一个宿主。通过将编码蛙皮素、杀菌肽或类似作用的杀寄生虫肽的基因引入并表达于蚊子基因组中，有可能在蚊子载体中诱导有效的传播阻断免疫。
