Zasloff M, Martin B, Chen H C
Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
Proc Natl Acad Sci U S A. 1988 Feb;85(3):910-3. doi: 10.1073/pnas.85.3.910.
We have previously reported the isolation of two broad-spectrum antimicrobial peptides ("magainins") from the skin of the African clawed frog Xenopus laevis. These natural peptides are active against many species of bacteria and fungi and also induce osmotic lysis of protozoa. In this report we demonstrate that synthetic magainin peptides appear to be indistinguishable from the natural products with respect to chromatographic properties and biological activity. These studies demonstrate conclusively that the magainin peptides are potent antimicrobial substances.
我们之前报道过从非洲爪蟾非洲爪蟾的皮肤中分离出两种广谱抗菌肽（“爪蟾抗菌肽”）。这些天然肽对多种细菌和真菌具有活性，还能诱导原生动物的渗透裂解。在本报告中，我们证明合成的爪蟾抗菌肽在色谱特性和生物活性方面似乎与天然产物没有区别。这些研究最终证明爪蟾抗菌肽是有效的抗菌物质。
