Choi Seong Hye, Park Sang Jun, Kim Na Rae
Department of Neurology, Inha University School of Medicine, Incheon, Korea.
Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon, Korea.
PLoS One. 2016 Sep 6;11(9):e0162202. doi: 10.1371/journal.pone.0162202. eCollection 2016.
We investigated the association of the macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thicknesses with disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD).
We recruited 42 patients with AD, 26 with MCI, and 66 normal elderly controls. The thicknesses of the RNFL and GCIPL were measured via spectral-domain optic coherent tomography in all participants at baseline. The patients with MCI or AD underwent clinical and neuropsychological tests at baseline and once every year thereafter for 2 years.
The Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) score exhibited significant negative relationships with the average GCIPL thickness (β = -0.15, p < 0.05) and the GCIPL thickness in the superotemporal, superonasal, and inferonasal sectors. The composite memory score exhibited significant positive associations with the average GCIPL thickness and the GCIPL thickness in the superotemporal, inferonasal, and inferotemporal sectors. The temporal RNFL thickness, the average and minimum GCIPL thicknesses, and the GCIPL thickness in the inferonasal, inferior, and inferotemporal sectors at baseline were significantly reduced in MCI patients who were converted to AD compared to stable MCI patients. The change of CDR-SB from baseline to 2 years exhibited significant negative associations with the average (β = -0.150, p = 0.006) and minimum GCIPL thicknesses as well as GCIPL thickness in the superotemporal, superior, superonasal, and inferonasal sectors at baseline.
Our data suggest that macular GCIPL thickness represents a promising biomarker for monitoring the progression of MCI and AD.
我们研究了黄斑神经节细胞-内丛状层（GCIPL）和视乳头周围视网膜神经纤维层（RNFL）厚度与轻度认知障碍（MCI）和阿尔茨海默病（AD）疾病进展的相关性。
我们招募了42例AD患者、26例MCI患者和66名正常老年对照。所有参与者在基线时通过光谱域光学相干断层扫描测量RNFL和GCIPL的厚度。MCI或AD患者在基线时以及此后每年进行一次临床和神经心理学测试，持续2年。
临床痴呆评定量表-方框总和（CDR-SB）评分与平均GCIPL厚度（β = -0.15，p < 0.05）以及颞上、鼻上和鼻下象限的GCIPL厚度呈显著负相关。综合记忆评分与平均GCIPL厚度以及颞上、鼻下和颞下象限的GCIPL厚度呈显著正相关。与病情稳定的MCI患者相比，转化为AD的MCI患者在基线时的颞侧RNFL厚度、平均和最小GCIPL厚度以及鼻下、下方和颞下象限的GCIPL厚度显著降低。从基线到2年CDR-SB的变化与平均（β = -0.150，p = 0.006）和最小GCIPL厚度以及基线时颞上、上方、鼻上和鼻下象限的GCIPL厚度呈显著负相关。
我们的数据表明，黄斑GCIPL厚度是监测MCI和AD进展的一个有前景的生物标志物。
