Lee Yung-Sung, Hsieh Yi-Ting, Huang Te-Hsuan, Chiou Jeng-Min, Peng Tao-Chun, Liu Yao-Lin, Chen Jen-Hau, Chen Yen-Ching
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Department of Ophthalmology, New Taipei Municipal Tucheng Hospital, New Taipei City, Taiwan.
Alzheimers Dement. 2025 Feb;21(2):e14437. doi: 10.1002/alz.14437. Epub 2024 Dec 23.
The retinal nerve fiber layer (RNFL) or ganglion cell-inner plexiform layer (GC-IPL) is associated with cognitive impairment. However, the relationship between retinal asymmetry and cognitive frailty (CF) remains unknown.
Two hundred twenty-two community-dwelling older adults were assessed starting in 2015 and underwent biennial cognitive and frailty evaluations until 2022. Retinal asymmetry was defined as the absolute interocular retinal difference. Generalized linear mixed models estimated the risk of CF over time.
Among the participants, 158 completed the 4-year follow-up. Greater baseline GC-IPL asymmetry was associated with worsening CF over time (adjusted odds ratio = 1.06; 95% confidence interval [CI] = 1.03, 1.10), with handgrip strength asymmetry significantly modifying this association (p= 0.02). GC-IPL asymmetry was associated with cognitive impairment ( = -1.69 × 10; 95% CI = -3.13 × 10, -0.25 × 10) but not with physical frailty. RNFL showed no significant association with CF.
Interocular GC-IPL asymmetry might be a new biomarker for CF in older adults.
Interocular ganglion cell-inner plexiform layer (GC-IPL) asymmetry was associated with impaired memory-frailty, with handgrip strength asymmetry significantly modifying this association. Interocular GC-IPL asymmetry was associated with cognitive impairment. Interocular retinal asymmetry might be a structural biomarker of cognitive frailty.
视网膜神经纤维层（RNFL）或神经节细胞 - 内网状层（GC - IPL）与认知障碍有关。然而，视网膜不对称与认知衰弱（CF）之间的关系尚不清楚。
从2015年开始对222名社区居住的老年人进行评估，并每两年进行一次认知和衰弱评估，直至2022年。视网膜不对称定义为两眼间视网膜绝对差异。广义线性混合模型估计随时间推移CF的风险。
在参与者中，158人完成了4年随访。基线时更大的GC - IPL不对称与随时间推移CF的恶化相关（调整后的优势比 = 1.06；95%置信区间[CI] = 1.03，1.10），握力不对称显著改变了这种关联（p = 0.02）。GC - IPL不对称与认知障碍相关（ = -1.69×10；95% CI = -3.13×10，-0.25×10），但与身体衰弱无关。RNFL与CF无显著关联。
两眼间GC - IPL不对称可能是老年人CF的一种新生物标志物。
两眼间神经节细胞 - 内网状层（GC - IPL）不对称与记忆衰弱受损有关，握力不对称显著改变了这种关联。两眼间GC - IPL不对称与认知障碍相关。两眼间视网膜不对称可能是认知衰弱的一种结构生物标志物。
