Almeida-Pititto Bianca de, Ribeiro-Filho Fernando Flexa, Barreto Sandhi, Duncan Bruce B, Schmidt Maria Inês, Lotufo Paulo A, Bensenor Isabela M, Ferreira Sandra R G
Faculdade de Saúde Pública, Universidade de São Paulo (FSP-USP), São Paulo, SP, Brasil.
Departamento de Medicina Interna, Universidade Federal do Pará (UFPA), Belém, PA, Brasil.
Arch Endocrinol Metab. 2016 Nov-Dec;60(6):573-581. doi: 10.1590/2359-3997000000205. Epub 2016 Sep 5.
Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD.
This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR.
Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes.
In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
我们的目标是在巴西成人健康纵向研究（ELSA）中无糖尿病或心血管疾病的中年人群子集中，描述根据年龄和性别分布的选定生物标志物，并对胰岛素抵抗稳态模型评估（HOMA-IR）和肥胖进行校正。
这项横断面研究在998名无糖尿病和/或心血管疾病的ELSA-Brasil参与者中进行。除了传统危险因素外，还根据性别、年龄组（35-44岁；45-54岁）和HOMA-IR三分位数比较了几种生物标志物浓度。采用线性回归分析性别和年龄与选定的新型生物标志物之间的独立关联，并对身体肥胖和HOMA-IR进行校正。
55%为女性。男性的体重指数、腰围、血压、血糖、HOMA-IR平均值高于女性，血脂谱更差，E-选择素水平更高，瘦素浓度更低；而女性的高密度脂蛋白胆固醇和瘦素水平高于男性。男女的腰围、收缩压、血糖和载脂蛋白B（Apo B）平均值均随年龄增长而增加。瘦素和E-选择素浓度在HOMA-IR三分位数中呈上升趋势。仅在男性中发现Apo B与年龄的独立关联，而在男女两性中均发现瘦素与体重指数和HOMA-IR、E-选择素与HOMA-IR的独立关联。
总之，我们的数据表明年龄、性别、肥胖以及由此导致的胰岛素抵抗会影响Apo B、瘦素和E-选择素的循环水平，这表明在对心血管代谢风险相对较低的个体进行研究或临床评估这些参数时，应考虑这些因素。
