3-Methylpseudouridine as a fermentation product.
作者信息
Nielsen J B, Arison B H
机构信息
Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
出版信息
J Antibiot (Tokyo). 1989 Aug;42(8):1248-52. doi: 10.7164/antibiotics.42.1248.
PMID:2759907
Abstract
3-Methylpseudouridine (beta isomer) has been identified in fermentation broths of Nocardia lactamdurans. It accumulates at quite high levels following the accumulation of extracellular uracil in strains exhibiting increased levels of de novo pyrimidine biosynthetic enzymes. It is labeled by exogenous uracil, and appears to result from an irreversible modification of one of the components of the elevated pyrimidine pool. Its methyl group is labeled efficiently by [methyl-14C]methionine.
摘要
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