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古细菌转运核糖核酸(tRNA)中取代核糖胸腺嘧啶的一种修饰核苷的结构。1-甲基假尿苷。

Structure of a modified nucleoside in archaebacterial tRNA which replaces ribosylthymine. 1-Methylpseudouridine.

作者信息

Pang H, Ihara M, Kuchino Y, Nishimura S, Gupta R, Woese C R, McCloskey J A

出版信息

J Biol Chem. 1982 Apr 10;257(7):3589-92.

PMID:7061499
Abstract

The structure of a modified nucleoside isolated from Halococcus morrhuae tRNA has been established as 1-methylpseudouridine, based on mass spectrometry and gas chromatography carried out on 0.2 A260 unit of material. Not previously found in nucleic acids, 1-methylpseudouridine appears to be unique to archaebacterial tRNA, where it replaces ribosylthymine in the T psi C loop of most of the tRNAs examined thus far.

摘要

基于对0.2个A260单位物质进行的质谱分析和气相色谱分析,从盐球菌属海藻tRNA中分离出的一种修饰核苷的结构已确定为1-甲基假尿苷。1-甲基假尿苷以前在核酸中未被发现,它似乎是古细菌tRNA所特有的,在迄今为止检测的大多数tRNA的TψC环中,它取代了核糖胸腺嘧啶。

相似文献

1
Structure of a modified nucleoside in archaebacterial tRNA which replaces ribosylthymine. 1-Methylpseudouridine.古细菌转运核糖核酸(tRNA)中取代核糖胸腺嘧啶的一种修饰核苷的结构。1-甲基假尿苷。
J Biol Chem. 1982 Apr 10;257(7):3589-92.
2
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1-methylpseudouridine, a metabolite of Streptomyces platensis.
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Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs.酵母tRNA的Tψ环中核糖胸苷和假尿苷酶促形成的主要身份决定因素。
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The presence of O-2'-methylpseudouridine in the 18S + 26S ribosomal ribonucleates of wheat embryo.小麦胚18S + 26S核糖体核糖核酸中O-2'-甲基假尿苷的存在。
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Structural characterization of U*-1915 in domain IV from Escherichia coli 23S ribosomal RNA as 3-methylpseudouridine.来自大肠杆菌23S核糖体RNA结构域IV的U*-1915被鉴定为3-甲基假尿苷的结构特征。
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Synthesis of 3-methylpseudouridine and 2'-deoxy-3-methyl-pseudouridine.
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3-Methylpseudouridine as a fermentation product.
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Determination of pseudouridine in tRNA and in acid-soluble tissue extracts by high-performance liquid chromatography.用高效液相色谱法测定tRNA和酸溶性组织提取物中的假尿苷。
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Pseudouridine-deficient transfer RNAs from Escherichia coli B and their use as substrates for pseudouridine synthetase.来自大肠杆菌B的假尿苷缺陷型转运RNA及其作为假尿苷合成酶底物的用途。
J Biol Chem. 1977 Sep 25;252(18):6310-5.

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N-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.mRNA 的 N-甲基假尿嘧啶化导致+1 核糖体移码。
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