Graduate School of Engineering, Nagoya University , Furo-cho, Chikusa, Nagoya 464-8603, Japan.
Org Lett. 2016 Sep 16;18(18):4462-5. doi: 10.1021/acs.orglett.6b01774. Epub 2016 Sep 7.
Regioselective synthetic methods were developed for 1,4- and 1,6-conjugate additions of Grignard reagent-derived organozinc(II)ates to malonate-derived polyconjugated esters. By taking advantage of the tight ion-pair control of organozinc(II)ates, it was possible to switch between 1,4- and 1,6-conjugate additions by introducing a terminal ethoxy moiety in the conjugation.
开发了区域选择性合成方法，用于格氏试剂衍生的有机锌（II）酸盐与丙二酸酯衍生的多共轭酯的 1,4-和 1,6-共轭加成。通过利用有机锌（II）酸盐的紧密离子对控制，可以通过在共轭物中引入末端乙氧基基团来在 1,4-和 1,6-共轭加成之间进行切换。
