Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Abdom Radiol (NY). 2016 Dec;41(12):2524-2532. doi: 10.1007/s00261-016-0890-9.
Sickle cell disease (SCD) is the most prevalent hemoglobinopathy. Survival in patients with SCD has improved over the past few decades. These patients experience a lifetime of repeated acute pain crises, which are thought to result from sickling and microvascular occlusions; acute abdominal pain is common. Moreover, repeated crises often lead to organ dysfunction, such as asplenia, hepatic failure, and renal failure. The spleen, liver, biliary system, kidneys, and gastrointestinal tract can all be affected. Patients may undergo CT to further direct clinical management. We review the spectrum of CT imaging findings of abdominal manifestations in patients with SCD, from the acute microvascular occlusive pain crisis to the potential complications and chronic sequelae.
镰状细胞病（SCD）是最常见的血红蛋白病。在过去的几十年中，SCD 患者的生存率有所提高。这些患者一生都会经历反复发作的急性疼痛危象，据认为这些疼痛危象是由镰状化和微血管阻塞引起的；急性腹痛很常见。此外，反复发作的危象常导致器官功能障碍，如脾切除、肝功能衰竭和肾功能衰竭。脾、肝、胆道系统、肾脏和胃肠道都可能受到影响。患者可能会进行 CT 检查以进一步指导临床管理。我们回顾了 SCD 患者腹部表现的 CT 成像表现谱，从急性微血管阻塞性疼痛危象到潜在的并发症和慢性后遗症。
