Lawman Hannah G, D Fryar Cheryl, Gu Qiuping, Ogden Cynthia L
Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland, USA.
Obesity (Silver Spring). 2016 Oct;24(10):2210-6. doi: 10.1002/oby.21600. Epub 2016 Sep 7.
Previous research has not investigated the role of prescription medication in sleep-obesity associations despite the fact that 56% of U.S. adults take at least one prescription medication.
Data from n = 16,622 adults in the National Health and Nutrition Examination Survey (2007-2012) were used to examine how the association between obesity and self-reported sleep duration varied by total number of prescription medications used in the past 30 days and by select classes of prescription medications including anxiolytics/sedatives/hypnotics, antidepressants, sleep aids, anticonvulsants, thyroid agents, and metabolic agents.
Logistic regression analyses showed a significant inverse linear association of sleep duration and obesity, regardless of the total number of prescription medications individuals were taking. Each additional hour of sleep was associated with a 10% decrease in the odds of obesity. Results suggest that increased sleep duration is associated with lower odds of having obesity overall, even for long-duration sleepers (≥9 h), and this association does not differ for those taking antidepressants, thyroid agents, metabolic agents, and multiple prescription medications.
The relationship between sleep duration and obesity was similar among all prescription medication users and nonusers. The potential for a nonlinear association between sleep duration and obesity may be important to examine in some specific prescription medication classes.
尽管有56%的美国成年人至少服用一种处方药，但先前的研究尚未调查处方药在睡眠-肥胖关联中的作用。
利用美国国家健康与营养检查调查（2007 - 2012年）中n = 16622名成年人的数据，来研究肥胖与自我报告的睡眠时间之间的关联如何因过去30天使用的处方药总数以及特定类别的处方药（包括抗焦虑药/镇静剂/催眠药、抗抑郁药、助眠药、抗惊厥药、甲状腺药物和代谢药物）而有所不同。
逻辑回归分析显示，无论个体服用的处方药总数如何，睡眠时间与肥胖之间均存在显著的负线性关联。睡眠时间每增加一小时，肥胖几率就会降低10%。结果表明，睡眠时间延长总体上与肥胖几率降低相关，即使对于睡眠时间较长者（≥9小时）也是如此，而且这种关联在服用抗抑郁药、甲状腺药物、代谢药物以及多种处方药的人群中并无差异。
在所有使用处方药和未使用处方药的人群中，睡眠时间与肥胖之间的关系相似。在某些特定类别的处方药中，研究睡眠时间与肥胖之间非线性关联的可能性可能很重要。
