Cooper P H
Department of Pathology, University of Virginia Medical Center, Charlottesville 22908.
J Cutan Pathol. 1989 Apr;16(2):81-4. doi: 10.1111/j.1600-0560.1989.tb00015.x.
This report describes 6 women with acantholytic lesions localized to the vulvocrural area. Clinically, multiple papules or solitary papules or plaques were situated on the labia majora or adjacent skin. None of the patients had similar abnormalities elsewhere on the body or family histories of similar eruptions. Two patients had concurrent candidal vaginitis. Microscopic findings consisted of acantholytic dyskeratosis resembling that observed in Darier's disease or acantholysis with minimal dyskeratosis similar to that seen in Hailey-Hailey disease. In one patient, acantholytic dyskeratosis with a cup-like configuration resembled the microscopic appearance of warty dyskeratoma. Immunofluorescence microscopy was negative in one patient. Solitary lesions were cured by local excision, but the papular eruption of one patient was recalcitrant to therapy. The literature contains descriptions of eight additional women with comparable lesions. Acantholytic reactions localized to the vulvocrural area are not apparently rare and need to be distinguished from other acantholytic dermatoses that can affect this anatomic site.
本报告描述了6名女性，其棘层松解性损害局限于外阴股部区域。临床上，多个丘疹或单个丘疹或斑块位于大阴唇或邻近皮肤。所有患者身体其他部位均无类似异常，也无类似皮疹的家族史。两名患者同时患有念珠菌性阴道炎。显微镜检查结果包括类似 Darier 病所见的棘层松解性角化不良，或类似 Hailey-Hailey 病所见的棘层松解且角化不良轻微。在一名患者中，呈杯状结构的棘层松解性角化不良类似于疣状角化不良瘤的显微镜表现。一名患者的免疫荧光显微镜检查为阴性。单个损害通过局部切除治愈，但一名患者的丘疹性皮疹对治疗顽固。文献中还描述了另外8名有类似损害的女性。局限于外阴股部区域的棘层松解反应显然并不罕见，需要与可累及该解剖部位的其他棘层松解性皮肤病相鉴别。
