Millns J L, Evans H L, Winkelmann R K
Am J Dermatopathol. 1979 Fall;1(3):273-809. doi: 10.1097/00000372-197900130-00015.
A 57-year-old man with generalized, subcutaneous fat necrosis was found at autopsy to have islet cell carcinoma of the pancreas. The histologic diagnosis of islet cell carcinoma was confirmed by the finding by electron microscopy of characteristic intracytoplasmic granules within pancreatic neoplastic cells. Lipase levels were elevated in serum as well as in tissues in areas of subcutaneous fat necrosis. Enzyme histochemical stains for alkaline and acid phosphatase, leucine, aminopeptidase, succinic dehydrogenase, and indoxyl and nonspecific esterase were positive in the areas of subcutaneous fat necrosis. This is the first report of the association of islet cell carcinoma of the pancreas with generalized subcutaneous fat necrosis.
一名57岁患有全身性皮下脂肪坏死的男性在尸检时被发现患有胰腺胰岛细胞癌。胰岛细胞癌的组织学诊断通过电子显微镜检查发现胰腺肿瘤细胞内有特征性的胞浆内颗粒得以证实。血清以及皮下脂肪坏死区域的组织中的脂肪酶水平均升高。碱性磷酸酶、酸性磷酸酶、亮氨酸氨基肽酶、琥珀酸脱氢酶、吲哚酚和非特异性酯酶的酶组织化学染色在皮下脂肪坏死区域呈阳性。这是胰腺胰岛细胞癌与全身性皮下脂肪坏死相关联的首例报告。
