Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, California.
San Francisco Veterans Affairs Medical Center, San Francisco, California.
J Am Geriatr Soc. 2016 Oct;64(10):2035-2041. doi: 10.1111/jgs.14313. Epub 2016 Sep 7.
To determine the prevalence and outcomes of breathlessness in older Americans.
Community-dwelling older adults.
Individuals aged 70 and older in the nationally representative Health and Retirement Study (2008, follow-up through 2012) (N = 3,671; mean age 78).
Breathlessness was assessed by asking the question, "How often do you become short of breath while awake?" Responses of often or sometimes were considered to represent a level of breathlessness sufficient to warrant clinical attention. The prevalence of breathlessness is described overall and in subpopulations, then rates of associated symptoms, well-being, and health services use of participants who were breathless are compared with rates of those who were not. The risk of decline in activities of daily living (ADLs) and death through 2012 was estimated by creating a multivariable Cox proportional hazards model, adjusting for age, sex, race and ethnicity, and education.
Twenty-five percent of participants reported breathlessness. The prevalence of breathlessness was higher in certain subpopulations: chronic lung disease (63%), multimorbidity (≥2 chronic conditions) (45%), current smokers (38%), heart disease (36%), obesity (body mass index ≥30.0 kg/m ) (33%), and education less than high school (32%). Breathlessness was associated with higher rates of depression, anxiety, and severe fatigue; lower ratings of well-being; and higher rates of clinic and emergency department visits and hospitalizations (all P < .001). Breathlessness predicted ADL decline over 5 years (adjusted hazard ratio (aHR) = 1.43, 95% confidence interval (CI) = 1.22-1.68) and death (aHR 1.62, 95% CI = 1.32-2.02).
One in four adults aged 70 and older in the United States experiences breathlessness, which is associated with lack of well-being, greater health services use, and a 40% greater risk of worsened function and 60% greater risk of death over the next 5 years.
确定美国老年人呼吸困难的患病率和结局。
社区居住的老年人。
全国代表性健康与退休研究(2008 年,随访至 2012 年)中年龄在 70 岁及以上的个体(N=3671;平均年龄 78 岁)。
通过询问“您在清醒时经常感到呼吸困难吗?”来评估呼吸困难。经常或有时的回答被认为是呼吸困难的程度足以引起临床关注。描述了呼吸困难的总体患病率和亚人群患病率,然后比较了有呼吸困难和没有呼吸困难的参与者的相关症状、幸福感和卫生服务利用情况。通过创建多变量 Cox 比例风险模型,调整年龄、性别、种族和民族以及教育程度,估计到 2012 年日常生活活动(ADL)下降和死亡的风险。
25%的参与者报告有呼吸困难。在某些亚人群中,呼吸困难的患病率更高:慢性肺部疾病(63%)、多种疾病(≥2 种慢性疾病)(45%)、当前吸烟者(38%)、心脏病(36%)、肥胖症(体重指数≥30.0kg/m )(33%)和受教育程度低于高中(32%)。呼吸困难与更高的抑郁、焦虑和严重疲劳发生率、更低的幸福感评分以及更高的诊所和急诊室就诊率和住院率相关(均 P<.001)。呼吸困难预示着 5 年内 ADL 下降(调整后的危险比(aHR)=1.43,95%置信区间(CI)=1.22-1.68)和死亡(aHR 1.62,95% CI = 1.32-2.02)。
在美国,每四个 70 岁及以上的成年人中就有一个人经历呼吸困难,这与幸福感下降、更多的卫生服务利用以及未来 5 年内功能恶化风险增加 40%和死亡风险增加 60%相关。