Ribaldone Davide G, Fagoonee Sharmila, Hickman Ingrid, Altruda Fiorella, Saracco Giorgio M, Pellicano Rinaldo
Unit of Gastroenterology, Molinette Hospital, Turin, Italy -
Minerva Cardioangiol. 2016 Dec;64(6):686-96. Epub 2016 Sep 7.
Despite the remarkable advances made in primary prevention and treatment, ischemic heart disease (IHD) remains the leading cause of death and a significant cause of disability in developed countries. Since traditional cardiovascular risk factors failed to predict all cases of IHD, there is an intensive research to explore other potential etiologic factors. Among these, numerous studies have considered the theoretical link between IHD and chronic infections, including Helicobacter pylori (H. pylori). Considering that epidemiologic studies have produced conflicting results, due to geographical variations of IHD and H. pylori prevalence as well as heterogeneity of study designs, an alternative way to analyze this topic is to assess if consistency for a biological plausibility exists. In this review we critically analyzed the experimental data on this topic, to assess whether their results could lead future clinical studies.
尽管在一级预防和治疗方面取得了显著进展，但缺血性心脏病（IHD）仍然是发达国家的主要死因和致残的重要原因。由于传统的心血管危险因素无法预测所有IHD病例，因此正在进行深入研究以探索其他潜在的病因。其中，许多研究考虑了IHD与慢性感染（包括幽门螺杆菌）之间的理论联系。鉴于流行病学研究结果相互矛盾，这归因于IHD和幽门螺杆菌患病率的地理差异以及研究设计的异质性，分析该主题的另一种方法是评估是否存在生物学合理性的一致性。在本综述中，我们批判性地分析了关于该主题的实验数据，以评估其结果是否能为未来的临床研究提供指导。
