Kim Dong-Hoon, Son Byoung Kwan, Min Kyueng-Whan, Han Sang Kuk, Na Ji Ung, Choi Pil Cho, Kim Hack-Lyoung, Kwon Mi Jung, Oh Young Ha, Jung Woon Yong, Moon Ji-Yong, Hong Sangmo, Oh Ki-Wook, Kim Young Seo
Departments of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
Department of Internal Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul 01830, Korea.
J Clin Med. 2020 Jun 14;9(6):1856. doi: 10.3390/jcm9061856.
Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels.
慢性胃炎可激活全身炎症反应，进而导致不良血脂谱。为确定慢性胃炎的严重程度，基于广泛用于组织学分级的更新悉尼系统（USS）评估幽门螺杆菌（HP）、单核细胞（淋巴细胞和浆细胞）及中性粒细胞评分。本研究旨在评估胃组织学特征与血脂谱水平之间的关系。本研究纳入了15322名男性和5929名女性，他们在江北三星医疗中心（KBSMC）进行了健康检查和胃活检。我们分析了根据USS得出的HP、单核细胞和中性粒细胞分级是否与血清白细胞计数、不良行为及血脂谱水平相关。伴有HP、中性粒细胞或中度至重度单核细胞的胃炎与血清白细胞计数升高有关。高白细胞计数与低密度脂蛋白（LDL）和甘油三酯/极低密度脂蛋白（VLDL）升高以及高密度脂蛋白（HDL）降低有关。在多变量分析中，伴有HP或中度至重度单核细胞的慢性胃炎与男性HDL降低显著相关，而单核细胞与女性HDL降低显著相关。慢性胃炎与全身炎症反应增加有关，这与不良血脂谱相关，尤其是低HDL水平。
