Zakrzewski Mateusz, Gornowicz Agnieszka, Zakrzewska Magdalena, Bielawska Anna, Maciorkowska Elżbieta
Department of Urology and Oncological Urology, Voivodeship Hospital in Lomza, 18-404 Lomza, Poland.
Department of Biotechnology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Int J Mol Sci. 2024 Nov 28;25(23):12780. doi: 10.3390/ijms252312780.
has been of interest to scientists and clinicians for many years, often causing diagnostic difficulties, especially in the youngest age group, in children. The presence of this bacterium in the population depends on the geographic region. However, it is assumed that even half of the world's population may be infected with . Children infected with -the study group (Hp(+)) and control group (Hp(-)), were chosen for further examination. The aim of the study was to analyze the concentrations of selected inflammatory markers in saliva (TNF-α, IL-8) and other markers (neutrophil defensin-1, sICAM-1, calprotectin, metalloproteinase-9, metalloproteinase-2, lactotransferrin, TLR-2) using ELISA technique. We confirmed the increased concentrations of IL-8, ND-1, and TLR-2 in the group of children infected with . Moreover, there was also a positive, significant correlation between the concentration of ND-1 and MMP-2, sICAM-1, and calprotectin as well as MMP-9 and MMP-2 in the group of infected children. The study created new possibilities of insight into the pathogenetic mechanisms of developing inflammation in the mouth. This type of comprehensive research is also used to monitor the current disease process and create new opportunities for better in-depth diagnostics of children infected with .
多年来一直引起科学家和临床医生的关注，常常造成诊断困难，尤其是在儿童这一年龄最小的群体中。这种细菌在人群中的存在情况取决于地理区域。然而，据推测，全球甚至可能有一半人口感染了[细菌名称未给出]。选择感染了[细菌名称未给出]的儿童——研究组（Hp(+)）和对照组（Hp(-)）进行进一步检查。本研究的目的是使用酶联免疫吸附测定（ELISA）技术分析唾液中选定的炎症标志物（TNF-α、IL-8）和其他标志物（中性粒细胞防御素-1、sICAM-1、钙卫蛋白、金属蛋白酶-9、金属蛋白酶-2、乳铁传递蛋白、TLR-2）的浓度。我们证实感染了[细菌名称未给出]的儿童组中IL-8、ND-1和TLR-2的浓度升高。此外，在感染儿童组中，ND-1与MMP-2、sICAM-1和钙卫蛋白以及MMP-9与MMP-2的浓度之间也存在正的显著相关性。该研究为深入了解口腔炎症发生的致病机制创造了新的可能性。这种类型的综合研究也用于监测当前的疾病进程，并为更好地深入诊断感染了[细菌名称未给出]的儿童创造新的机会。
