Elliott Karen L, Fritzsch Bernd, Duncan Jeremy S
Department of Biology, University of Iowa, Iowa City, IA, United States.
Department of Biological Sciences, Western Michigan University, Kalamazoo, MI, United States.
Front Cell Neurosci. 2018 Aug 8;12:252. doi: 10.3389/fncel.2018.00252. eCollection 2018.
We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss.
我们回顾了柯蒂氏器毛细胞的进化与发育，重点关注它们与前庭毛细胞在分子层面的差异。要在扁平上皮中对柯蒂氏器毛细胞发育进行治疗性引导，并生成不同毛细胞类型的正确排列、静纤毛的方向以及动纤毛的延迟消失（这些对于听力均至关重要），同时避免促使毛细胞向前庭命运发展，就需要此类信息。突出与前庭器官的差异并明确关于这些差异调控的已知情况，将有助于聚焦未来的研究方向，以在长期毛细胞损失后成功恢复柯蒂氏器。
