镍催化的 8-氨基喹啉 C5 位的位点选择性 C-H 键双氟烷基化反应。
Nickel-Catalyzed Site-Selective C-H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position.
机构信息
Department of Chemistry, Huaibei Normal University , Huaibei, Anhui 235000, P. R. China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , Shanghai 200032, P. R. China.
出版信息
Org Lett. 2016 Oct 7;18(19):4794-4797. doi: 10.1021/acs.orglett.6b02166. Epub 2016 Sep 9.
A simple and efficient protocol for nickel-catalyzed regioselective C-H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope and provides a facile and useful access to the corresponding C5-functionalized difluoromethylated quinolines in good to excellent yields.
发展了一种镍催化的 8-氨基喹啉骨架与功能化二氟甲基溴的区域选择性 C-H 键双氟烷基化的简单高效的反应方案。该反应具有广泛的底物范围，为相应的 C5 官能化的二氟甲基化喹啉提供了一种简便有效的方法，产率良好至优秀。
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