Zhao Ruinan, Yang Yaocheng, Wang Xia, Ren Peng, Zhang Qian, Li Dong
School of Materials and Chemical Engineering, Hubei University of Technology Wuhan 430068 China
School of Science, Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China.
RSC Adv. 2018 Nov 5;8(65):37064-37068. doi: 10.1039/c8ra07647b. eCollection 2018 Nov 1.
A highly efficient nickel/silver co-catalyzed C-H amination at the C5 position of 8-aminoquinolines with azodicarboxylates at room temperature is reported. The reaction undergoes a self-redox process without the necessity of external oxidant. It proceeded under simple and mild conditions without any additional ligand, base or oxidant and provided the desired products in good to excellent yields. This method also possessed the merits of good functional group compatibility and air and moisture tolerance. It provides an efficient strategy for the synthesis of useful quinoline derivatives.
据报道，在室温下，一种高效的镍/银共催化体系可实现8-氨基喹啉C5位与偶氮二甲酸酯的C-H胺化反应。该反应经历自氧化还原过程，无需外部氧化剂。反应在简单温和的条件下进行，无需任何额外的配体、碱或氧化剂，能以良好至优异的产率得到目标产物。该方法还具有官能团兼容性好、对空气和湿气耐受性强的优点。它为有用的喹啉衍生物的合成提供了一种有效策略。
