University of British Columbia, Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, V6T 1Z3 Vancouver, BC, Canada.
Cell Res. 2016 Oct;26(10):1073-1074. doi: 10.1038/cr.2016.106. Epub 2016 Sep 9.
Ryanodine Receptors are large ion channels responsible for the release of Ca from the Endoplasmic and Sarcoplasmic Reticulum, a prerequisite for muscle contraction. Recent cryo-electron microscopy data have allowed a direct visualization of allosteric motions within these membrane protein giants.
Ryanodine 受体是一种大的离子通道，负责从内质网和肌浆网中释放 Ca，这是肌肉收缩的前提。最近的低温电子显微镜数据允许对这些膜蛋白巨无霸中的变构运动进行直接可视化。
