如何打开兰尼碱受体。
How to open a Ryanodine Receptor.
机构信息
University of British Columbia, Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, V6T 1Z3 Vancouver, BC, Canada.
出版信息
Cell Res. 2016 Oct;26(10):1073-1074. doi: 10.1038/cr.2016.106. Epub 2016 Sep 9.
Abstract
Ryanodine Receptors are large ion channels responsible for the release of Ca from the Endoplasmic and Sarcoplasmic Reticulum, a prerequisite for muscle contraction. Recent cryo-electron microscopy data have allowed a direct visualization of allosteric motions within these membrane protein giants.
摘要
Ryanodine 受体是一种大的离子通道，负责从内质网和肌浆网中释放 Ca，这是肌肉收缩的前提。最近的低温电子显微镜数据允许对这些膜蛋白巨无霸中的变构运动进行直接可视化。
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本文引用的文献
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Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.对兰尼碱受体1（RyR1）的Ca(2+)激活的远程变构通道门控的结构见解。
Cell Res. 2016 Sep;26(9):977-94. doi: 10.1038/cr.2016.99. Epub 2016 Aug 30.
2
The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening.兰尼碱受体1（RyR1）的中央结构域是通道开放远程变构门控的信号转导器。
Cell Res. 2016 Sep;26(9):995-1006. doi: 10.1038/cr.2016.89. Epub 2016 Jul 29.
3
The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.心肌兰尼碱受体的胞质Ca2+激活并不需要EF手型Ca2+结合结构域。
J Biol Chem. 2016 Jan 29;291(5):2150-60. doi: 10.1074/jbc.M115.693325. Epub 2015 Dec 9.
4
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.兔兰尼碱受体RyR1近原子分辨率结构
Nature. 2015 Jan 1;517(7532):50-55. doi: 10.1038/nature14063. Epub 2014 Dec 15.
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Structure of a mammalian ryanodine receptor.哺乳动物兰尼碱受体的结构。
Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1.
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Architecture and conformational switch mechanism of the ryanodine receptor.兰尼碱受体的结构与构象转换机制。
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