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Hypoxia potentially promotes Tibetan longevity.

作者信息

Li Yan, Wang Ming-Shan, Otecko Newton O, Wang Wen, Shi Peng, Wu Dong-Dong, Zhang Ya-Ping

机构信息

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China.

State Key Laboratory of Genetic Resources and Evolution, Chinese Academy of Sciences, Kunming 650223, China.

出版信息

Cell Res. 2017 Feb;27(2):302-305. doi: 10.1038/cr.2016.105. Epub 2016 Sep 9.

DOI:10.1038/cr.2016.105
PMID:27608935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5339844/
Abstract
摘要

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Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the Global Burden of Disease Study 2013.1990-2013 年中国 240 种疾病的特定病因死亡率：2013 年全球疾病负担研究的国家间系统分析。
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Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.秀丽隐杆线虫中的缺氧延长寿命需要 HIF-1 和 DAF-16，并且受到 SKN-1 的拮抗。
J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1135-44. doi: 10.1093/gerona/glt016. Epub 2013 Feb 18.
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The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.基因组分析工具包：一种用于分析下一代 DNA 测序数据的 MapReduce 框架。
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Genetic evidence for high-altitude adaptation in Tibet.遗传证据表明西藏存在高原适应现象。
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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.通过 RNA-Seq 进行转录本组装和定量分析揭示了细胞分化过程中未注释的转录本和异构体转换。
Nat Biotechnol. 2010 May;28(5):511-5. doi: 10.1038/nbt.1621. Epub 2010 May 2.
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Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.鉴定安第斯人群适应高海拔的正选择候选基因座。
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