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CD147/EMMPRIN 过表达与癌症预后：系统评价和荟萃分析。

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis.

机构信息

Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Jiangan District, 430022 Wuhan P. R. China.

Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Qiaokou District, 430030 Wuhan P. R. China.

出版信息

Sci Rep. 2016 Sep 9;6:32804. doi: 10.1038/srep32804.

DOI:10.1038/srep32804
PMID:27608940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5016850/
Abstract

CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched PubMed and Embase databases to screen the literature. Fixed-effect and random-effect meta-analytical techniques were used to correlate CD147 expression with outcome measures. A total of 53 studies that included 68 datasets were eligible for inclusion in the final analysis. We found a significant association between CD147/EMMPRIN overexpression and adverse tumor outcomes, such as overall survival, disease-specific survival, progression-free survival, metastasis-free survival or recurrence-free survival, irrespective of the model analysis. In addition, CD147/EMMPRIN overexpression predicted a high risk for chemotherapy drugs resistance. CD147/EMMPRIN is a central player in tumor progression and predicts a poor prognosis, including in patients who have received chemo-radiotherapy. Our results provide the evidence that CD147/EMMPRIN could be a potential therapeutic target for cancers.

摘要

CD147/EMMPRIN（细胞外基质金属蛋白酶诱导因子）在肿瘤进展中起着重要作用，许多研究表明它是肿瘤预后的指标。本荟萃分析系统地重新评估了 CD147/EMMPRIN 在各种癌症中的预测潜力。我们检索了 PubMed 和 Embase 数据库以筛选文献。使用固定效应和随机效应荟萃分析技术将 CD147 表达与结局指标相关联。共有 53 项研究，包含 68 个数据集，符合最终分析的纳入标准。我们发现 CD147/EMMPRIN 过表达与不良肿瘤结局（如总生存期、疾病特异性生存期、无进展生存期、无转移生存期或无复发生存期）之间存在显著关联，而与模型分析无关。此外，CD147/EMMPRIN 过表达预示着对化疗药物耐药的高风险。CD147/EMMPRIN 是肿瘤进展的核心参与者，预示着预后不良，包括接受放化疗的患者。我们的结果提供了证据表明 CD147/EMMPRIN 可能是癌症的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/a65741138010/srep32804-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/0461dc1aa289/srep32804-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/4c08c8e52cb6/srep32804-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/38c0af947cab/srep32804-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/b4b1952b1af4/srep32804-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/dff9e2b1c46d/srep32804-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/a65741138010/srep32804-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/0461dc1aa289/srep32804-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/4c08c8e52cb6/srep32804-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/38c0af947cab/srep32804-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/b4b1952b1af4/srep32804-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/dff9e2b1c46d/srep32804-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22a8/5016850/a65741138010/srep32804-f6.jpg

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