Nugrahani Rista Widhi, Rahniayu Alphania, Mastutik Gondo
Department of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Medical Staff of Anatomic Pathology Laboratory, Dr Soetomo General Academic Hospital, Surabaya, Indonesia.
Asian Pac J Cancer Prev. 2025 Mar 1;26(3):1001-1007. doi: 10.31557/APJCP.2025.26.3.1001.
Colorectal cancer is the third malignant tumor and the second cause of death in the world. There are several prognostic factors in colorectal adenocarcinoma, one of which is the TNM stage. The T stage is determined based on the depth of tumor invasion. Various proteins can be involved in the invasion process. EMMPRIN is expressed and functions on the surface of cancerous cells. as a mediator of tumor cell invasion. Increased β-Catenin accelerates the process of tumor cell proliferation, migration, and invasion. We aimed to analyze the correlation between EMMPRIN and β-Catenin expression in the T stages of colorectal adenocarcinoma.
An observational analytic study was conducted using a cross-sectional approach on 47 paraffin blocks of colorectal adenocarcinoma at the Anatomic Pathology Laboratory of Dr. Soetomo Hospital Surabaya from January 2018 to December 2022. An immunohistochemical examination was performed using EMMPRIN and β-Catenin antibodies, and then the expression of both antibodies will be analyzed using statistical tests.
There was a significant correlation between the expression of β-Catenin with various T stages of colorectal adenocarcinoma (p-value 0.0201). There was a significant correlation between the expression of EMMPRIN and β-Catenin in various T-stages of colorectal adenocarcinoma (p-value: 0.0209).
There is a positive correlation between EMMPRIN and β-Catenin expression and various T-stages of colorectal adenocarcinoma with weak strength. The existence of EMMPRIN and β-Catenin stimulates colorectal cancer cells to continue invasion.
结直肠癌是全球第三大恶性肿瘤和第二大致死原因。结直肠腺癌有多种预后因素，其中之一是TNM分期。T分期是根据肿瘤浸润深度确定的。多种蛋白质可能参与浸润过程。细胞外基质金属蛋白酶诱导因子（EMMPRIN）在癌细胞表面表达并发挥作用，作为肿瘤细胞侵袭的介质。β-连环蛋白增加会加速肿瘤细胞增殖、迁移和侵袭过程。我们旨在分析结直肠腺癌T分期中EMMPRIN与β-连环蛋白表达之间的相关性。
采用横断面研究方法，对2018年1月至2022年12月在泗水苏托莫博士医院解剖病理实验室的47例结直肠腺癌石蜡块进行观察性分析研究。使用EMMPRIN和β-连环蛋白抗体进行免疫组织化学检查，然后使用统计检验分析两种抗体的表达情况。
β-连环蛋白表达与结直肠腺癌的不同T分期之间存在显著相关性（p值为0.0201）。EMMPRIN和β-连环蛋白在结直肠腺癌不同T分期中的表达之间存在显著相关性（p值：0.0209）。
EMMPRIN和β-连环蛋白表达与结直肠腺癌不同T分期之间存在正相关，强度较弱。EMMPRIN和β-连环蛋白的存在刺激结直肠癌细胞持续侵袭。
