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CD147在人胃癌中的表达与肿瘤复发及预后相关。

CD147 expression in human gastric cancer is associated with tumor recurrence and prognosis.

作者信息

Chu Dake, Zhu Shaojun, Li Jipeng, Ji Gang, Wang Weizhong, Wu Guosheng, Zheng Jianyong

机构信息

State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; State Key Laboratory of Cancer Biology and Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.

Department of Pathology, Tangdu Hospital, Fourth Military Medical University. Xi'an, Shaanxi, China.

出版信息

PLoS One. 2014 Jun 30;9(6):e101027. doi: 10.1371/journal.pone.0101027. eCollection 2014.

DOI:10.1371/journal.pone.0101027
PMID:24979746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4076217/
Abstract

CD147 is correlated with tumor aggressiveness in various human malignancies. Here, we investigated CD147 protein expression in 223 patients with gastric cancer by immunohistochemistry and analyzed its association with disease-free and overall survival. CD147 was increased in gastric cancer compared to normal tissues. Additionally, CD147 expression was associated with gastric cancer invasion, metastasis and TNM stage, whereas it was not related to age, sex, differentiation status, tumor site or Lauren classification. Kaplan-Meier analysis confirmed that CD147 was associated with disease-free and overall survival in patients with gastric cancer; i.e., patients with positive CD147 staining tend to have worse disease-free and overall survival. Moreover, Cox's proportional hazards analysis demonstrated that CD147 was an independent marker of disease-free and overall survival for patients with gastric cancer. These results confirm the association of CD147 with gastric cancer invasion and metastasis and prove that CD147 might be an indicator of tumor recurrence and prognosis in gastric cancer.

摘要

CD147与多种人类恶性肿瘤的肿瘤侵袭性相关。在此，我们通过免疫组织化学研究了223例胃癌患者中CD147蛋白的表达情况，并分析了其与无病生存期和总生存期的关联。与正常组织相比，胃癌中CD147表达增加。此外，CD147表达与胃癌的侵袭、转移及TNM分期相关，而与年龄、性别、分化状态、肿瘤部位或Lauren分类无关。Kaplan-Meier分析证实，CD147与胃癌患者的无病生存期和总生存期相关；即CD147染色阳性的患者往往无病生存期和总生存期较差。此外，Cox比例风险分析表明，CD147是胃癌患者无病生存期和总生存期的独立标志物。这些结果证实了CD147与胃癌侵袭和转移的关联，并证明CD147可能是胃癌肿瘤复发和预后的一个指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/51a27c70b8f7/pone.0101027.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/71b5b20529f1/pone.0101027.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/ae5675d82803/pone.0101027.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/51a27c70b8f7/pone.0101027.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/71b5b20529f1/pone.0101027.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/ae5675d82803/pone.0101027.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90c4/4076217/51a27c70b8f7/pone.0101027.g003.jpg

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