Lim Joo Hyun, Kim Sang Gyun, Song Ji Hyun, Hwang Jae Jin, Lee Dong Ho, Han Jae Pil, Hong Su Jin, Kim Ji Hyun, Jeon Seong Woo, Kim Gwang Ha, Shim Ki-Nam, Shin Woon Geon, Kim Tae Ho, Kim Sun Moon, Chung Il-Kwon, Kim Hyun-Soo, Kim Heung Up, Lee Joongyub, Kim Jae Gyu
Department of Internal Medicine, Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul, Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Gut Liver. 2017 Mar 15;11(2):226-231. doi: 10.5009/gnl16099.
BACKGROUND/AIMS: The resistance rate of is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line eradication in peptic ulcer disease.
Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed.
The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton-pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/gastroduodenal ulcer, 68.8%, p=0.655).
Levofloxacin-based third-line eradication showed efficacy similar to that of previously reported first/second-line therapies.
背景/目的：[某种细菌]的耐药率正在逐渐上升。我们旨在评估以左氧氟沙星为基础的三线[细菌]根除疗法在消化性溃疡疾病中的疗效。
2002年至2014年期间，14个医疗中心的110例患者接受了以左氧氟沙星为基础的三线消化性溃疡疾病根除治疗。其中，88例被纳入研究；21例因缺乏随访而被排除，1例因依从性差而被排除。分析了他们的根除率、治疗方案和疗程以及消化性溃疡的类型。
总体根除率为71.6%。依从率为80.0%。除1例患者外，所有患者均接受了质子泵抑制剂、阿莫西林和左氧氟沙星治疗。1例患者接受了质子泵抑制剂、阿莫西林、左氧氟沙星和克拉霉素治疗，且根除成功。31例患者接受了7天的治疗，25例接受了10天的治疗，32例接受了14天的治疗。三组之间的根除率无显著差异（7天组为80.6%，10天组为64.0%，14天组为68.8%，p = 0.353）。此外，根据消化性溃疡的类型，根除率也没有差异（胃溃疡为73.2%，十二指肠溃疡/胃十二指肠溃疡为68.8%，p = 0.655）。
以左氧氟沙星为基础的三线[细菌]根除疗法显示出与先前报道的一线/二线疗法相似的疗效。
