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盐酸妥拉唑啉对自由放养的沙漠骡鹿中盐酸赛拉嗪-盐酸氯胺酮麻醉作用的逆转

Reversal by tolazoline hydrochloride of xylazine hydrochloride-ketamine hydrochloride immobilizations in free-ranging desert mule deer.

作者信息

DelGiudice G D, Krausman P R, Bellantoni E S, Etchberger R C, Seal U S

机构信息

Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.

出版信息

J Wildl Dis. 1989 Jul;25(3):347-52. doi: 10.7589/0090-3558-25.3.347.

DOI:10.7589/0090-3558-25.3.347
PMID:2761006
Abstract

We captured 10 free-ranging desert mule deer (Odocoileus hemionus crooki) (five males and five females) by net-gun from a helicopter and immobilized them with xylazine hydrochloride (HCl) (100 mg) and ketamine HCl (300 to 400 mg) injected intramuscularly. Arousal and ambulation times were 13.9 +/- 4.2 and 14.3 +/- 4.2 min in eight deer injected intravenously with tolazoline HCl (3.0 mg/kg). We observed a curvilinear relationship (R = 0.50, P less than 0.01) between rectal temperature and time after induction of anesthesia. Mean peak temperature (41.4 C) occurred at 23.7 +/- 3.2 min postinduction and was greater (P less than 0.01) than the mean temperature measured initially (40.8 C). Heart and respiratory rates (108 beats/min and 75 breaths/min) were elevated prior to immobilization. Mean heart rate increased (P less than 0.05) from 90 +/- 9 beats/min in anesthetized deer to 120 +/- 13 beats/min after tolazoline HCl injection. A 20% capture-related mortality rate suggests this combination of physical and chemical capture has serious limitations. Captive deer permitted to recover from xylazine HCl-ketamine HCl immobilization without a reversal agent were able to walk in 290 +/- 79 min.

摘要

我们从直升机上用网枪捕获了10只自由放养的沙漠骡鹿(Odocoileus hemionus crooki)(5只雄性和5只雌性),并用盐酸赛拉嗪(100毫克)和盐酸氯胺酮(300至400毫克)肌肉注射使其麻醉。对8只静脉注射盐酸妥拉唑啉(3.0毫克/千克)的鹿进行观察,其苏醒时间和行走时间分别为13.9±4.2分钟和14.3±4.2分钟。我们观察到直肠温度与麻醉诱导后的时间呈曲线关系(R = 0.50,P<0.01)。平均峰值温度(41.4℃)出现在诱导后23.7±3.2分钟,高于初始测量的平均温度(40.8℃)(P<0.01)。在麻醉前,心率和呼吸频率(分别为108次/分钟和75次/分钟)升高。平均心率从麻醉鹿的90±9次/分钟增加(P<0.05)到注射盐酸妥拉唑啉后120±13次/分钟。20%的捕获相关死亡率表明这种物理和化学捕获的组合存在严重局限性。在没有使用苏醒剂的情况下,从盐酸赛拉嗪-盐酸氯胺酮麻醉中恢复的圈养鹿能够在290±79分钟内行走。

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