关于遗传因素对绝经后女性人格特质及其对生活质量影响的分析。
Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors.
作者信息
Schneider-Matyka Daria, Jurczak Anna, Samochowiec Agnieszka, Karakiewicz Beata, Szkup Małgorzata, Grzywacz Anna, Grochans Elżbieta
机构信息
Department of Nursing, Pomeranian Medical University in Szczecin, ul. Żołnierska 48, 71-210 Szczecin, Poland.
Department of Clinical Psychology, Institute of Psychology, University of Szczecin, Szczecin, Poland.
出版信息
Ann Gen Psychiatry. 2016 Sep 8;15(1):25. doi: 10.1186/s12991-016-0110-6. eCollection 2016.
BACKGROUND
Quality of life can be perceived as a subjective assessment of different aspects of human functioning. Personality is a factor which determines actions taken by individuals and their tendency to perceive reality in a particular way. Therefore, the assumption that personality may influence the QoL assessment seems reasonable. Our purpose was to assess the relationships between personality traits and the presence of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. We also wanted to determine the influence of personality on the quality of life of postmenopausal women.
METHODS
The study involved 214 postmenopausal women from northwest Poland. It was conducted using the NEO-FFI and the SF-36 questionnaires. DNA polymorphisms were identified using the polymerase chain reaction (PCR).
RESULTS
The average age of the women was 56.8 ± 4.08 years. Half of the respondents had completed second-level education, 69.2 % had life partners, and 53.3 % were professionally active. Women with the 3/3 genotype were characterized by significantly lower openness to experience than respondents with other MAO-A genotypes (p < 0.05). There was a significant correlation between the quality of life and the levels of neuroticism and extroversion, as well as between selected quality of life domains and the levels of agreeableness and conscientiousness.
CONCLUSIONS
(1)Women with the 3/3 genotype of the 30-bp VNTR polymorphism in the MAO-A promoter region are characterized by lower levels of openness to experience than women with other MAO-A genotypes in our study (2) Personality traits may contribute to the assessment of the quality of life.
背景
生活质量可被视为对人类功能不同方面的主观评估。人格是决定个体行为及其以特定方式感知现实倾向的一个因素。因此，人格可能影响生活质量评估这一假设似乎是合理的。我们的目的是评估人格特质与5-羟色胺转运体（SLC 6A4）启动子区域44碱基对可变数目串联重复序列（VNTR）多态性以及单胺氧化酶A（MAO-A）启动子区域30碱基对VNTR多态性之间的关系。我们还想确定人格对绝经后女性生活质量的影响。
方法
该研究纳入了来自波兰西北部的214名绝经后女性。研究采用了大五人格问卷简式版（NEO-FFI）和36项简短健康调查量表（SF-36）。使用聚合酶链反应（PCR）鉴定DNA多态性。
结果
这些女性的平均年龄为56.8 ± 4.08岁。一半的受访者完成了中等教育，69.2%有生活伴侣，53.3%在职业上较为活跃。与具有其他MAO-A基因型的受访者相比，具有3/3基因型的女性在经验开放性方面显著较低（p < 0.05）。生活质量与神经质和外向性水平之间存在显著相关性，以及在选定的生活质量领域与宜人性和尽责性水平之间也存在显著相关性。
结论
（1）在我们的研究中，MAO-A启动子区域30碱基对VNTR多态性的3/3基因型女性在经验开放性方面低于具有其他MAO-A基因型的女性。（2）人格特质可能有助于生活质量的评估。
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