Zonderman A B, Costa P T, McCrae R R
Gerontology Research Center, National Institute on Aging, Baltimore, Md 21224.
JAMA. 1989 Sep 1;262(9):1191-5.
The relative risks for cancer morbidity and mortality associated with depressive symptoms were examined using data from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. The Center for Epidemiologic Studies Depression scale and the depression subscale from the General Well-being Schedule were used as predictors in this 10-year follow-up study of a nationally representative sample. No significant risk for cancer morbidity or mortality was associated with depressive symptoms with or without adjustment for age, sex, marital status, smoking, family history of cancer, hypertension, and serum cholesterol level. These data were also reanalyzed for subjects aged 55 years or older who were retraced by a second follow-up. Neither measure of depressive symptoms was a significant risk for cancer death during the 15-year follow-up interval. These results call into question the causal connection between depressive symptoms and cancer morbidity and mortality.
利用来自美国国家健康与营养检查调查I流行病学随访研究的数据，对与抑郁症状相关的癌症发病率和死亡率的相对风险进行了研究。在这项对全国代表性样本的10年随访研究中，使用了流行病学研究中心抑郁量表和总体幸福感量表中的抑郁分量表作为预测指标。无论是否对年龄、性别、婚姻状况、吸烟、癌症家族史、高血压和血清胆固醇水平进行调整，抑郁症状与癌症发病率或死亡率均无显著关联。对年龄在55岁及以上且通过第二次随访进行追踪的受试者的数据也进行了重新分析。在15年的随访期内，两种抑郁症状测量指标均不是癌症死亡的显著风险因素。这些结果使人对抑郁症状与癌症发病率和死亡率之间的因果关系产生质疑。
