日本成人T细胞白血病的细胞遗传学研究。

Cytogenetic studies on the adult T-cell leukemia in Japan.

作者信息

Fujita K, Yamasaki Y, Sawada H, Izumi Y, Fukuhara S, Uchino H

机构信息

Department of Internal Medicine, Kokura Memorial Hospital, Kitakyushu, Japan.

出版信息

Leuk Res. 1989;13(7):535-43. doi: 10.1016/0145-2126(89)90120-3.

DOI:10.1016/0145-2126(89)90120-3

PMID:2761289

Abstract

Cytogenetic studies were performed on 16 patients with ATL seen in Northern Kyushu island; nine were patients with acute type leukemia, one with crisis type and five with lymphoma type. The serum antibody for HTLV-1 (ATLA) was positive in all patients and the phenotype of ATL cells were ERFC+, OKT3+, OKT4+, OKT6-, OKT8-, OKT10+, OKla1+/- and Tac+. Abnormal findings of chromosomes were observed in 15 patients. Thirteen patients were in near diploid range. One patient was in triploid range and one patient was in tetraploid range. The polyploid karyotypes were found only in lymphoma type patients. Trisomy 3 and trisomy 7 were observed each in three patients with acute type of ATL. The most frequent abnormal rearrangement was observed in the long arm of chromosome 6 and the break occurred at band 6q15 and 6q21 each in four patients in this series.

摘要

对在九州岛北部就诊的16例成人T细胞白血病（ATL）患者进行了细胞遗传学研究；其中9例为急性白血病型患者，1例为危象型患者，5例为淋巴瘤型患者。所有患者的人类嗜T淋巴细胞病毒1型（HTLV-1）血清抗体（成人T细胞白血病相关抗体）均为阳性，ATL细胞的表型为ERFC+、OKT3+、OKT4+、OKT6-、OKT8-、OKT10+、OKla1+/-和Tac+。15例患者观察到染色体异常。13例患者处于近二倍体范围。1例患者处于三倍体范围，1例患者处于四倍体范围。多倍体核型仅在淋巴瘤型患者中发现。在3例急性型ATL患者中分别观察到三体3和三体7。在该系列中，最常见的异常重排在6号染色体长臂上，4例患者的断裂分别发生在6q15和6q21带。