Hoque M M, Adnan S D, Karim S, Mamun M A, Nandy S, Faruki M A, Islam K
Professor Dr Md Mazharul Hoque, Professor, Department of Transfusion Medicine, Dhaka Medical College, Dhaka, Bangladesh.
Mymensingh Med J. 2016 Jul;25(3):485-91.
Iron stores in the body exist primarily in the form of ferritin. Small amounts of ferritin secreted into the plasma and plasma ferritin is positively correlated with the size of the total body iron stores. The present study conducted to determine the iron status using the serum ferritin level among healthy Bangladeshi blood donors. The present cross sectional study was conducted in the Department of Transfusion Medicine, Dhaka Medical College, Dhaka, Bangladesh from July 2011 to June 2012. Blood donor signed informed consent and has satisfactory pre-donation health assessment and satisfactory post-donation blood test results were included in the study. Full blood counts were performed within 4 hours of collection using an automated haematology analyzer. Serum ferritin was measured using a validated enzyme immunoassay. Data were analyzed using SPSS version 16 (SPPS Incorporation, Chicago, IL, USA). P value <0.05 was considered as statistically significant. Total 100 blood donors were included in the study, among them 88 were male and 12 were female. Mean±SD of the age of the respondents was 26.8±5.9 years with a range of 19 to 45 years. Mean±SD of heamoglobin level (gm/dl) and total count of Red Blood Cell (million/cmm) were 14.1±1.4 and 5.1±0.4 respectively. Mean±SD of serum ferritin level (ng/ml) was 96.4±69.0ng/ml with a range of 4.1ng/ml to 298.7ng/ml. Among the respondents 9.0% had depleted iron store, 7.0 reduced iron store and 84.0% had normal iron store. Among the respondents 5.0% had iron deficiency anaemia in term of serum ferritin level. Statistically significant difference of serum ferritin level observed between male and female and donors with and without history of previous blood donation. Among the healthy blood donors of Bangladesh abnormal serum ferritin is highly prevalent among blood donors specially among female. Monitoring of iron stores by serum ferritin seems justified in order to identify those with depleted iron stores who will benefit from iron supplementation.
体内的铁储备主要以铁蛋白的形式存在。少量铁蛋白分泌到血浆中，血浆铁蛋白与全身铁储备量呈正相关。本研究旨在通过血清铁蛋白水平来确定孟加拉国健康献血者的铁状态。本横断面研究于2011年7月至2012年6月在孟加拉国达卡达卡医学院输血医学系进行。签署知情同意书且献血前健康评估令人满意、献血后血液检测结果令人满意的献血者被纳入研究。使用自动血液分析仪在采血后4小时内进行全血细胞计数。使用经过验证的酶免疫测定法测量血清铁蛋白。使用SPSS 16版（美国伊利诺伊州芝加哥市SPPS公司）分析数据。P值<0.05被认为具有统计学意义。本研究共纳入100名献血者，其中88名男性，12名女性。受访者的平均年龄±标准差为26.8±5.9岁，年龄范围为19至45岁。血红蛋白水平（克/分升）和红细胞总数（百万/立方毫米）的平均±标准差分别为14.1±1.4和5.1±0.4。血清铁蛋白水平（纳克/毫升）的平均±标准差为96.4±69.0纳克/毫升，范围为4.1纳克/毫升至298.7纳克/毫升。在受访者中，9.0%的人铁储备耗尽，7.0%的人铁储备减少，84.0%的人铁储备正常。根据血清铁蛋白水平，受访者中有5.0%患有缺铁性贫血。观察到男性与女性以及有和无既往献血史的献血者之间血清铁蛋白水平存在统计学显著差异。在孟加拉国的健康献血者中，异常血清铁蛋白在献血者中高度普遍，尤其是在女性中。通过血清铁蛋白监测铁储备似乎是合理的，以便识别那些铁储备耗尽且将从铁补充剂中受益的人。
