Nelson Deborah B, Rockwell L Christie, Prioleau Morgan D, Goetzl Laura
Department of Epidemiology and Biostatistics, College of Public Health, Temple University, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, Temple University, USA.
Department of Anthropology, College of Liberal Arts, Temple University, USA.
Anaerobe. 2016 Dec;42:67-73. doi: 10.1016/j.anaerobe.2016.09.001. Epub 2016 Sep 6.
Recent assessments have examined the composition of bacterial communities influencing reproductive, pregnancy and infant health. The Microbiome Project has made great strides in sequencing the microbiome and identifying the vast communities of microorganisms that inhabit our bodies and much work continues to examine the individual contribution of bacteria on health and disease to inform future therapies. This review explores the current literature outlining the contribution of important bacteria on reproductive health among sexually active men and women, outlines gaps in current research to determine causal and interventional relationships, and suggests future research initiatives. Novel treatments options to reduce adverse outcomes must recognize the heterogeneity of the bacteria within the microbiome and adequately assess long-term benefits in reducing disease burden and re-establishing a healthy Lactobacillus-dominant state. Recognizing other reservoirs outside of the lower genital track and within sexual partners as well as genetic and individual moderators may be most important for long-term cure and reduction of disease. It will be important to develop useful screening tools and comprehensively examine novel therapeutic options to promote the long-term reduction of high-risk bacteria and the re-establishment of healthy bacterial levels to considerably improve outcomes among pregnant women and sexually active men and women.
近期的评估研究了影响生殖、妊娠和婴儿健康的细菌群落组成。微生物组计划在对微生物组进行测序以及识别栖息于我们体内的大量微生物群落方面取得了巨大进展，并且仍有许多工作在继续探究细菌对健康和疾病的个体作用，以为未来的治疗提供依据。本综述探讨了当前文献，概述了重要细菌对性活跃男女生殖健康的贡献，明确了当前研究中在确定因果关系和干预关系方面存在的差距，并提出了未来的研究倡议。减少不良后果的新治疗方案必须认识到微生物组内细菌的异质性，并充分评估在减轻疾病负担和重建以乳酸杆菌为主导的健康状态方面的长期益处。认识到下生殖道之外以及性伴侣体内的其他细菌储存库，以及基因和个体调节因素，对于疾病的长期治愈和减少可能最为重要。开发有用的筛查工具并全面研究新的治疗方案，以促进长期减少高危细菌并重建健康的细菌水平，从而显著改善孕妇以及性活跃男女的健康状况，这一点至关重要。
