Hutchison K J, Campbell J D, Karpinski E
Department of Physiology, University of Alberta, Edmonton, Canada.
Microvasc Res. 1989 Jul;38(1):102-9. doi: 10.1016/0026-2862(89)90019-8.
The infusion of polyacrylamide in open chest rats has been reported to increase aortic blood flow and the effect has been ascribed to the "drag reduction" properties of these compounds. In six anesthetized dogs the infusion of polyacrylamide to a total dose of 2 mg/kg caused a reduction in midline and separation zone Doppler spectral broadening in the common carotid artery poststenotic velocity field. This apparent reduction in poststenotic turbulence was interpreted as indicating the presence of a drag reducing effect. Despite this demonstration that polyacrylamide was present in the blood in drag reducing concentrations no increase in aortic blood flow was produced.
据报道，向开胸大鼠输注聚丙烯酰胺可增加主动脉血流量，该效应归因于这些化合物的“减阻”特性。在6只麻醉犬中，输注总量为2mg/kg的聚丙烯酰胺可使颈总动脉狭窄后速度场的中线和分离区多普勒频谱增宽减小。狭窄后湍流的这种明显减小被解释为表明存在减阻效应。尽管已证明血液中存在具有减阻浓度的聚丙烯酰胺，但并未使主动脉血流量增加。
