Rock Kenneth L, Reits Eric, Neefjes Jacques
Department of Pathology, UMass Medical School, Worcester, MA, USA.
Department of Cell Biology and Histology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Trends Immunol. 2016 Nov;37(11):724-737. doi: 10.1016/j.it.2016.08.010. Epub 2016 Sep 7.
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.
自MHC分子被发现以来，已经过去了40年，才形成了关于MHC I类和MHC II类分子实际工作方式的连贯图景。这是一个关于蛋白酶和MHC样伴侣蛋白的故事，它们在将肽呈递给免疫系统的过程中支持MHC I类和II类分子。我们现在明白，MHC系统塑造了呈递肽的库以及随后的T细胞反应，其重要影响范围从移植排斥到肿瘤免疫疗法。在这里，我们对MHC I类和MHC II类抗原呈递的来龙去脉进行了图文并茂的综述。
