Department of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing Health Sciences, Taiwan.
Department of Neurology, En Chu Kong Hospital, Sanxia District, New Taipei City, Taiwan.
Environ Int. 2016 Nov;96:75-81. doi: 10.1016/j.envint.2016.08.017. Epub 2016 Sep 9.
Ambient air pollution has been associated with many health conditions, but little is known about its effects on neurodegenerative diseases, such as Parkinson's disease (PD). In this study, we investigated the influence of ambient air pollution on PD in a nationwide population-based case-control study in Taiwan.
We identified 11,117 incident PD patients between 2007 and 2009 from the Taiwanese National Health Insurance Research Database and selected 44,468 age- and gender-matched population controls from the longitudinal health insurance database. The average ambient pollutant exposure concentrations from 1998 through the onset of PD were estimated using quantile-based Bayesian Maximum Entropy models. Basing from logistic regression models, we estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of ambient pollutant exposures and PD risk.
We observed positive associations between NO, CO exposures, and PD. In multi-pollutant models, for NO and CO above the 75th percentile exposure compared with the lowest percentile, the ORs of PD were 1.37 (95% CI=1.23-1.52) and 1.17 (95% CI=1.07-1.27), respectively.
This study suggests that ambient air pollution exposure, especially from traffic-related pollutants such as NO and CO, increases PD risk in the Taiwanese population.
环境空气污染与许多健康状况有关，但对其对神经退行性疾病（如帕金森病（PD））的影响知之甚少。在这项研究中，我们在台湾进行了一项全国性基于人群的病例对照研究，调查了环境空气污染对 PD 的影响。
我们从台湾全民健康保险研究数据库中确定了 2007 年至 2009 年间的 11117 例新发 PD 患者，并从纵向健康保险数据库中选择了 44468 名年龄和性别匹配的人群对照。使用基于分位数的贝叶斯最大熵模型来估计 1998 年至 PD 发病期间的平均环境污染物暴露浓度。基于逻辑回归模型，我们估计了环境污染物暴露与 PD 风险的比值比（OR）和 95%置信区间（CI）。
我们观察到 NO 和 CO 暴露与 PD 之间存在正相关关系。在多污染物模型中，与最低分位相比，NO 和 CO 暴露在前 75 分位时，PD 的 OR 分别为 1.37（95% CI=1.23-1.52）和 1.17（95% CI=1.07-1.27）。
这项研究表明，环境空气污染暴露，特别是来自交通相关污染物（如 NO 和 CO）的暴露，会增加台湾人群患 PD 的风险。
