关于儿童抗磷脂综合征，已知哪些信息？
What is known about pediatric antiphospholipid syndrome?
机构信息
a Rheumatology , Gaetano Pini Institute, Center of Pediatric Rheumatology, Chair of Rheumatology, University of Milan , Milan , Italy.
b Experimental Laboratory of Immunorheumatology , IRCCS Istituto Auxologico Italiano , Cusano Milanino , Italy.
出版信息
Expert Rev Hematol. 2016 Oct;9(10):977-85. doi: 10.1080/17474086.2016.1235969.
INTRODUCTION
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy morbidity associated with the persistent presence of antiphospholipid antibodies (aPL) including lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and anti-β2 glycoprotein I antibodies (aβ2GPI).
AREAS COVERED
APS is considered as the most common acquired hypercoagulation state of autoimmune origin in children. Unfortunately, data about incidence, prevalence, thrombosis risk and effective treatment in paediatric APS are limited and unmethodical. Expert commentary: This review summarizes recent clinical, laboratory and therapy characterization of paediatric APS and emphasizes the differences between paediatric and adult populations.
简介
抗磷脂综合征（APS）是一种以血管血栓形成和/或与持续存在抗磷脂抗体（aPL）相关的妊娠并发症为特征的系统性自身免疫性疾病，包括狼疮抗凝物（LA）、抗心磷脂抗体（aCL）和抗β2糖蛋白 I 抗体（aβ2GPI）。
涵盖领域
APS 被认为是儿童最常见的自身免疫性获得性高凝状态。不幸的是，关于儿科 APS 的发病率、患病率、血栓形成风险和有效治疗的数据有限且不系统。
专家评论
本综述总结了儿科 APS 的最新临床、实验室和治疗特征，并强调了儿科和成人人群之间的差异。
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