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小鼠BALB/c 3T3细胞的一种生长因子反应基因编码一种与人组织因子同源的蛋白质。

A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor.

作者信息

Hartzell S, Ryder K, Lanahan A, Lau L F, Nathan D

机构信息

Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

出版信息

Mol Cell Biol. 1989 Jun;9(6):2567-73. doi: 10.1128/mcb.9.6.2567-2573.1989.

DOI:10.1128/mcb.9.6.2567-2573.1989
PMID:2761539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362329/
Abstract

Polypeptide growth factors rapidly induce the transcription of a set of genes that appear to mediate cell growth. We report that one of the genes induced in BALB/c mouse 3T3 cells encodes a transmembrane protein (mTF) homologous to human tissue factor, which is involved in the proteolytic activation of blood clotting. mTF mRNA is present in many murine tissues and cell lines. Our results raise the possibility that mTF may also play a role in cell growth.

摘要

多肽生长因子能迅速诱导一组似乎介导细胞生长的基因的转录。我们报告称，在BALB/c小鼠3T3细胞中诱导产生的一个基因编码一种与人类组织因子同源的跨膜蛋白（mTF），人类组织因子参与血液凝固的蛋白水解激活过程。mTF mRNA存在于许多小鼠组织和细胞系中。我们的结果提出了mTF也可能在细胞生长中发挥作用的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/e881325eca2f/molcellb00054-0291-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/3d85dfd6e694/molcellb00054-0288-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/0d5ce1b413a1/molcellb00054-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/d0235925cf22/molcellb00054-0291-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/e881325eca2f/molcellb00054-0291-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/3d85dfd6e694/molcellb00054-0288-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/0d5ce1b413a1/molcellb00054-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/d0235925cf22/molcellb00054-0291-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bf/362329/e881325eca2f/molcellb00054-0291-c.jpg

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