Demir Merve, Ramos-Rivera Laura, Silva Raquel, Nazhat Showan N, Boccaccini Aldo R
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, 91058, Germany.
Department of Mining and Materials Engineering, McGill University, 3610 University Street, Montreal, Quebec, H3A 0C5, Canada.
J Biomed Mater Res A. 2017 Jun;105(6):1656-1665. doi: 10.1002/jbm.a.36040. Epub 2017 Mar 27.
Considerable research efforts have been devoted to zein-based biomaterials for tissue engineering and other biomedical applications over the past decade. The attention given to zein-based polymers is primarily attributed to their biocompatibility and biodegradability. However, due to the relatively low mechanical properties of these polymers, numerous inorganic compounds (e.g., hydroxyapatite, calcium phosphate, bioactive glasses, natural clays) have been considered in combination with zein to create composite materials in an attempt to enhance zein mechanical properties. Inorganic phases also positively impact on the hydrophilic properties of zein matrices inducing a suitable environment for cell attachment, spreading, and proliferation. This review covers available literature on zein and zein-based composite materials, with focus on the combination of zein with commonly used inorganic fillers for tissue engineering and drug delivery applications. An overview of the most recent advances in fabrication techniques for zein-based composites is presented and key applications areas and future developments in the field are highlighted. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1656-1665, 2017.
在过去十年中，人们投入了大量的研究精力来开发用于组织工程和其他生物医学应用的基于玉米醇溶蛋白的生物材料。对基于玉米醇溶蛋白的聚合物的关注主要归因于它们的生物相容性和生物降解性。然而，由于这些聚合物的机械性能相对较低，人们考虑将多种无机化合物（如羟基磷灰石、磷酸钙、生物活性玻璃、天然粘土）与玉米醇溶蛋白结合，以制备复合材料，试图提高玉米醇溶蛋白的机械性能。无机相还对玉米醇溶蛋白基质的亲水性产生积极影响，从而为细胞附着、铺展和增殖创造适宜的环境。本综述涵盖了关于玉米醇溶蛋白和基于玉米醇溶蛋白的复合材料的现有文献，重点关注玉米醇溶蛋白与用于组织工程和药物递送应用的常用无机填料的结合。本文概述了基于玉米醇溶蛋白的复合材料制造技术的最新进展，并突出了该领域的关键应用领域和未来发展方向。© 2017威利期刊公司。《生物医学材料研究杂志》A部分：105A：1656 - 1665，2017年。
