van der Kraan P M
Experimental Rheumatology, Radboudumc, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Osteoarthritis Cartilage. 2017 Mar;25(3):369-375. doi: 10.1016/j.joca.2016.09.005. Epub 2016 Sep 9.
Osteoarthritis (OA) is the most common joint disease but an effective pharmacological therapy has not been developed yet. To identify targets for treatment and ways to interfere with OA development and progression both spontaneous and induced OA models are still needed. In this narrative review it is discussed what variables can be identified that lead to variation in OA animal model studies.
Literature was screened (Pubmed) with the following terms; OA animal models in combination with species, age, strain, gender/sex, housing, diet, fighting, circadian rhythm, transgenic. Relevant articles were selected and additional papers were searched for and read for specific subtopics.
Studies with OA models are subject to a multitude of variables, stimuli and conditions that can influence the outcome of an animal experiment. Outcome will depend on amongst others; the model used, species and strain, age, gender, diet, housing conditions, circadian rhythm, timing of intervention, stress levels and activity. Variations in these variables can account for discrepancies between OA model experiments, intervention studies and conclusions.
To improve OA animal model research, investigators should be aware of all the stimuli and conditions that can interfere with disease development and disease intervention and take these into account in their study design and execution.
骨关节炎（OA）是最常见的关节疾病，但尚未开发出有效的药物治疗方法。为了确定治疗靶点以及干扰OA发生和发展的方法，仍然需要自发和诱导性OA模型。在这篇叙述性综述中，讨论了哪些变量会导致OA动物模型研究出现差异。
使用以下术语在文献数据库（PubMed）中进行筛选：OA动物模型，并结合物种、年龄、品系、性别/性、饲养、饮食、争斗、昼夜节律、转基因。选择相关文章，并针对特定子主题搜索和阅读其他论文。
OA模型研究受到多种变量、刺激因素和条件的影响，这些因素会影响动物实验的结果。结果尤其取决于以下因素：所使用的模型、物种和品系、年龄、性别、饮食、饲养条件、昼夜节律、干预时机、应激水平和活动量。这些变量的差异可能导致OA模型实验、干预研究和结论之间存在差异。
为了改进OA动物模型研究，研究人员应了解所有可能干扰疾病发展和疾病干预的刺激因素和条件，并在研究设计和实施过程中加以考虑。
