Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Medical Sciences Center, #B-25, 1300 University Avenue, Madison, WI 53706, USA.
Carcinogenesis. 2012 Mar;33(3):483-91. doi: 10.1093/carcin/bgr305. Epub 2011 Dec 22.
The Wnt/β-catenin signaling pathway, one of the most conserved intercellular signaling cascade, is a known regulator of cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival and adhesion. Because aberrant Wnt/β-catenin signaling has been observed in a variety of human cancers including a majority of colorectal cancers, about half of prostate cancers and a third of melanomas, inhibitors of its complex signaling pathways are being investigated for therapy as well as chemoprevention of these cancers. During the last decade, several naturally occurring dietary agents have been shown to target intermediates in the Wnt/β-catenin signaling pathway. In this review, we highlight the current understanding of the Wnt/β-catenin signaling pathway and present an analysis of the key findings from laboratory studies on the effects of a panel of dietary agents against a variety of cancers. Promise of these agents for treating and preventing human cancer is then discussed.
Wnt/β-连环蛋白信号通路是最保守的细胞间信号级联之一，是已知的调节与肿瘤起始和进展、细胞增殖、分化、存活和黏附相关的细胞功能的调节剂。因为异常的 Wnt/β-连环蛋白信号在多种人类癌症中都有观察到，包括大多数结直肠癌、约一半的前列腺癌和三分之一的黑色素瘤，因此其复杂信号通路的抑制剂正在被研究用于治疗以及这些癌症的化学预防。在过去的十年中，已经有几种天然存在的膳食因子被证明可以靶向 Wnt/β-连环蛋白信号通路的中间产物。在这篇综述中，我们强调了对 Wnt/β-连环蛋白信号通路的现有理解，并对一系列膳食因子对多种癌症的影响的实验室研究的关键发现进行了分析。然后讨论了这些因子在治疗和预防人类癌症方面的应用前景。
