Ropio Joana, Merlio Jean-Philippe, Soares Paula, Chevret Edith
Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France.
Institute of Biomedical Sciences of Abel Salazar, University of Porto, Porto 4050-313, Portugal.
Genes (Basel). 2016 Sep 7;7(9):61. doi: 10.3390/genes7090061.
Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.
端粒酶表达和端粒维持对于细胞增殖和存活至关重要，并且它们在发育和癌症（包括血液系统恶性肿瘤）中发挥重要作用。人端粒酶逆转录酶基因（hTERT）限速亚基的转录调控是一个复杂的过程，揭示其重新激活背后的机制是开发诊断和治疗应用的重要一步。在此，我们综述端粒酶激活的主要机制及相关的血液系统恶性肿瘤。
