Cozzolino Mauro, Nasioudis Dimitrios, Sisti Giovanni, Coccia Maria Elisabetta
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Florence, Italy.
Gynecol Obstet Invest. 2017;82(2):105-112. doi: 10.1159/000449198. Epub 2016 Sep 13.
The study aimed to examine all available evidence regarding primary vaginal cancer arising from endometriosis from an evidence-based perspective.
A literature search in Medline and EMBASE databases was conducted. The following key words were employed: 'vaginal cancer' AND 'endometriosis malignant transformation' OR 'endometriosis'.
A total of 23 eligible studies were identified and included in the present review providing information for 37 patients. Endometrioid adenocarcinoma (17 cases) was the most common histological subtype followed by endometrial stromal sarcoma (6 cases). The majority of patients received cancer-directed surgery while adjuvant treatment was commonly employed for patients with sarcomas.
Vaginal cancer arising from endometriosis is exceedingly rare. The mainstay of treatment is surgical excision. Mean follow-up of patients was relative short. Tumor recurrence was often observed, and the outcome was less favorable for patients with non-epithelial tumors.
本研究旨在从循证医学角度审视有关子宫内膜异位症引发原发性阴道癌的所有现有证据。
在Medline和EMBASE数据库中进行文献检索。使用了以下关键词：“阴道癌”以及“子宫内膜异位症恶变”或“子宫内膜异位症”。
共确定了23项符合条件的研究并纳入本综述，这些研究提供了37例患者的信息。子宫内膜样腺癌（17例）是最常见的组织学亚型，其次是子宫内膜间质肉瘤（6例）。大多数患者接受了针对癌症的手术，而辅助治疗常用于肉瘤患者。
子宫内膜异位症引发的阴道癌极为罕见。治疗的主要方法是手术切除。患者的平均随访时间相对较短。经常观察到肿瘤复发，非上皮性肿瘤患者的预后较差。
